4 synonym groups for Chronic

Deep-rooted problems, ingrained problems, established problems, fixed problems, deep-seated problems, embedded problems, chronic problems, persistent problems, enduring problems, long-standing problems, entrenched issues, deep-rooted issues, ingrained issues, established issues, fixed issues, deep-seated issues, embedded issues, chronic issues, persistent issues, enduring issues, long-standing issues [x]

persistent issue, enduring problem, chronic problem, ongoing issue, perpetual problem, continuous problem, long-term issue, unending problem, constant issue, never-ending problem, recurring issue, sustained problem, interminable problem, ceaseless problem, unrelenting issue, protracted problem, enduring issue, long-lasting problem, perennial problem, abiding issue, unceasing problem, intractable problem, permanent issue, unremitting problem, unyielding problem, unending issue, continuous issue, chronic issue, perpetual issue, ongoing problem, lasting issue, long-standing problem, persistent problem, long-term problem, ceaseless issue, never-ending issue, recurring problem, sustained issue, interminable issue, unrelenting problem, protracted issue, abiding problem, unceasing issue, intractable issue, permanent problem, unremitting issue, unyielding issue [x]

suffering, agony, torment, distress, anguish, misery, affliction,, woe, discomfort, hurt, ache, sorrow, grief, tribulation, adversity, ordeal, trial, burden, malaise, throes, pangs, twinge, torture, excruciation, wretchedness, desolation, despair, lamentation, rue, mortification, heartache, heartbreak, dolour, unease, disquiet, perturbation, vexation, chagrin, dismay, consternation, discomposure, fretfulness, restlessness, uneasiness, worry, anxiety, stress [x]

persistent issue, ongoing problem, chronic problem, lasting issue, perpetual problem, continuous problem, enduring issue, long-term problem, recurring problem, sustained problem, unending problem, ceaseless problem, never-ending problem, constant problem, interminable problem, unrelenting problem, unremitting problem, abiding problem, perennial problem, intractable problem, protracted problem, long-standing problem, lingering problem, unyielding problem, steadfast problem, unceasing problem, relentless problem, unbroken problem, unflagging problem, unvarying problem, unchanging problem, unshakable problem, unalterable problem, immutable problem, unending issue, ceaseless issue, never-ending issue, constant issue, interminable issue, unrelenting issue, unremitting issue, abiding issue, perennial issue, intractable issue, protracted issue, long-standing issue, lingering issue, unyielding issue, steadfast issue [x]